Abaloparatide ntụ ntụ

Kedu ihe bụ Abaloparatide ntụ ntụ

Abaloparatide ntụ ntụ bụ peptide mejupụtara 34 amino acid fọdụrụnụ. Ọ bụ peptide hormone metụtara parathyroid (PTHrP) ọhụrụ nke RadiosHealth mepụtara. Ọ bụ ihe dị mkpa picky activator nke PTH-I receptor, nke nwere ike dịkwuo ọkpụkpụ ịnweta ọdịnaya, ọkpụkpụ viscosity, na ọkpụkpụ ike, na-akwalite ọkpụkpụ conformation, na e kwadoro site FDA na April 28, 2017. Aha ahia ya bụ Tymos. A na-eji injection nke abapatide subcutaneous agwọ osteoporosis n'ime ụmụ nwanyị postmenopausal na-eyi egwu mgbaji ma ọ bụ na-adịghị arụ ọrụ na ọgwụ ọgwụgwọ ndị ọzọ, nke nwere ike ibelata mgbasa nke ọkpụkpụ vertebral ọhụrụ na nke na-abụghị vertebral. E jiri ya tụnyere tripeptide, ọ nwere ike ibelata oke mgbaji na hypercalcemia.

Ọ bụ onye na-arụ ọrụ nke parathyroid hormone receptor (PTH1 receptor), na n'ihi oke osteogenic arụ ọrụ ya, a na-akwalite ọgwụ ndị sitere na abapatide maka mmepe ụlọ ọgwụ maka ọgwụgwọ osteoporosis postmenopausal na ụmụ nwanyị nwere nnukwu ihe egwu nke mgbaji.

Basic Ozi

Aha ngwaahịa: Abaloparatide

CAS: 247062-33-5

MF:C174H300N56O49

MW: 3960.5896

Usoro:Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu- Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2

Ịdị ọcha: 99%+

ngwugwu: 1g; 5g; 100g

MOQ: 1g

Si: China

ngwugwu: 1g; 5g; 10g

Eji: API

Nkwụsi ike: Stable

Oge Mbuga ozi: 3-7days

Usoro usoro:

Nka na ụzụ nkọwapụta:

ọrụ:

(1) Na-akwalite mmepụta insulin

Abaloparatide ntụ ntụ nwere ike ịkpali mkpụrụ ndụ islet pancreatic na-ezobe insulin, si otú a na-ebelata ọkwa shuga dị n'ọbara. Na mgbakwunye, ọ nwekwara ike ịbawanye mmetụta nke insulin, Mee ka ọ dịkwuo irè.

(2) Na-egbochi nsị nke gastric acid
ọ nwere ike igbochi nsị nke gastric acid, si otú ahụ na-ebelata mkpali nke mucosa gastric site na gastric acid na ime ka ahụ erughị ala n'ime afọ.
3) Na-achịkwa ndakpọ nke ihe na-eto eto dị ka insulin
ọ nwere ike ịkwalite njikọ nke insulin-dị ka ihe na-eto eto, si otú ahụ na-akwalite mmụba cell na ikewapụ ya, na-ekere òkè ụfọdụ n'ụdị cell na rejuvenescence.

ngwa:

Ngwa Abapaptide na-apụtakarị n'akụkụ ndị a:

(1) Mbelata ọkwa shuga dị n'ọbara

Ọ nwere ike ịkwalite mmepụta insulin ma belata ọkwa shuga dị n'ọbara, nke dị mkpa karịsịa maka ndị na-arịa ọrịa shuga.

(2) Na-ebelata ahụ erughị ala afọ

Ọ nwere ike igbochi secretion acid gastric ma belata ahụ erughị ala afọ, na-enye ụfọdụ ahụ efe maka mgbaàmà dịka mgbu afọ na mgbaze.

(3) Na-akwalite nrụzi cell na mmụgharị

Ọ nwere ike ịkwalite njikọ nke insulin-dị ka ihe na-eto eto, na-eduga n'ịbawanye cell na ọdịiche dị iche iche, na-enwe mmetụta ụfọdụ na nrụzi cell na ịmaliteghachi, na-enye ụfọdụ enyemaka na ọgwụgwọ ọnya na nrụzi anụ ahụ.

Na nchịkọta, Ọ bụ biomolecule dị oke mkpa nke nwere ọtụtụ ọrụ ndu na mmetụta ọgwụ, na-ekere òkè dị ukwuu na ahụike mmadụ.

Usoro nkwadebe

Abapa peptide bụ polypeptide nke mejupụtara 34 amino acid residues. Usoro nke Abapa peptide nwere ikike ka ewepụtara. Nke mbụ, a na-eji usoro njikọ siri ike -phase synthesize 3 peptide resin iberi. CHICALBOOK Nkeji 1 ejikọrọ. Otú ọ dị, a chọrọ usoro ihicha oyi kpọnwụrụ tupu nkwụsị nke peptide iberibe 2 na 3, na ọgbọ nke peptide resin iberibe 2 na 3 chọrọ nnukwu ego nke 2-CTC resin dị oke ọnụ, na-eme ka ọnụ ahịa mmepụta ihe dịkwuo elu.

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